Fig. 5. Aberrant BMZ assembly in developing Lama5 –/– skin is corrected with exogenous laminin-10. Follicular BMZ in Lama5 –/– skin (–/–), Lama5 –/– skin treated with laminin-10 (–/–, +L10) and Lama5 +/+ skin was analyzed 5 days after grafting, using transmission electron microscopy. Note the discontinuity of the lamina densa (LD) in areas between hemidesmosomes (HD) in Lama5 –/– skin (indicated by brackets), and its correction after treatment of Lama5 –/– skin with exogenous laminin-10. Bar = 250 nm.