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. Author manuscript; available in PMC: 2006 Sep 5.
Published in final edited form as: J Natl Cancer Inst. 1999 Dec 15;91(24):2087–2095. doi: 10.1093/jnci/91.24.2087

Fig. 2.

Fig. 2

Loss of heterozygosity (LOH) along the Barrett’s epithelial segment in individual patients. Six examples of patients with different LOH patterns. OS (ora serrata) and LES (lower esophageal sphincter) are endoscopic features used to define the region of Barrett’s within the esophagus. cm = location along the esophagus in centimeters from the incisors; sort = type of sample sorted (either Ki67-positive G1, Ki67-negative 2N, 4N [normal G2/M], Inc 4N [increased 4N], or aneuploid); open circles = no LOH; filled circles = LOH; and hatched circles = alternate allele lost. A) Case No. 252, single clone; B) case No. 916, change in ploidy; C) case No. 994, accumulation of loss; D) case No. 368 and E) case No. 790, mutually exclusive clones; and F) case No. 306, alternate allele patterns. Asterisk indicates a different LOH pattern along the same chromosome, i.e., different extent of loss.