Table 1.

Response to selection for resistance to pexiganan. (Positive lines were cultured in medium supplemented with pexiganan, whereas control lines were cultured in unsupplemented medium. Minimum inhibitory concentration (MIC) was measured using serial macrodilution of pexiganan. Each determination was made on two independent replicates from each line.)

organism	lineages	selection treatments	no. of lines	MIC ranges
before selection	after selection
Pseudomonas fluorescens	SBW25	positive	6	2–8	768–1024
		control	2	4	48–96
	SBW25 Δmuts	positive	6	16–32	1024+
		control	2	32	48–96
Escherichia coli	PS8	positive	4	32–128	768–1024
		control	2	64	128
	PS8 mutL	positive	6	16–256	512–1024
		control	2	32–64	48–64