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Options for calculating overlap probability πXC.
| Case | πXC calculated as | Comment |
| 1 | πC·πX | C and X are independent |
| 2 | πC|X·πX | C and X interact and πC|X or πX|C is known. |
| 3 | πX|C·πC | |
| 4 | πC·πX / [πC + (1 - πC) / RRX|C] | C and X are dependent and the relative risk RRX|C or RRC|X is known. |
| 5 | πX·πC / [πX + (1 - πX) / RRC|X] | X (C) either potentiates, or protects from, C (X). |
| 6 | πX·πC·k |
