Table 1.

Results of the time-dependent Cox regression models for (a) parental cultures along eight weeks post-challenge, (b) parental cultures along four weeks post-challenge and (c) offspring cultures along eight weeks post-challenge. (The tables contain the relevant terms identified by a backward stepwise procedure. See also the electronic supplementary material.)

factorsa	bb	s.e.c	Waldd	d.f.	pe	oddsf
(a)
F0-treatment			76.98	2	<0.001
F0-Ringer versus F0-naive	1.62	0.20	66.98	1	<0.001	5.09
F0-LPS versus F0-naive	1.57	0.20	61.65	1	<0.001	4.79
F0-LPS versus F0-Ringerg	0.06	0.16	0.15	1	0.702	1.06
T×F0-treatment			69.68	2	<0.001
T×F0-Ringer	−0.29	0.04	54.84	1	<0.001	0.75
T×F0-LPS	−0.29	0.04	56.71	1	<0.001	0.74
(b)
F0-treatment			46.86	2	<0.001
F0-Ringer versus F0-naive	2.52	0.38	43.89	1	<0.001	12.46
F0-LPS versus F0-naive	2.46	0.38	41.61	1	<0.001	11.66
F0-LPS versus F0-Ringerg	−0.07	0.22	0.09		0.764	0.93
T×F0-treatment			23.94	2	<0.001
T×F0-Ringer	−0.56	0.12	22.04	1	<0.001	1.75
T×F0-LPS	−0.53	0.12	19.97	1	<0.001	1.03
(c)
F0-treatment			11.59	2	0.003
F0-Ringer versus F0-naive	−0.07	0.03	4.53	1	0.033	0.93
F0-LPS versus F0-naive	−0.11	0.03	11.37	1	0.001	0.89
F0-LPS versus F0-Ringerg	−0.41	0.03	1.59	1	0.207	0.96
F1-treatment			5.97	2	0.050
F1-Ringer versus F1-naive	0.15	0.11	1.82	1	0.18	1.16
F1-LPS versus F1-naive	0.28	0.11	5.96	1	0.015	1.32
F1-LPS versus F1-Ringerg	0.12	0.11	1.21	1	0.271	1.13
F0-treatment×F1-treatment			10.37	4	0.035
F0-Ringer×F1-Ringer	−0.19	0.08	5.64	1	0.018	0.83
F0-LPS×F1-Ringer	0.01	0.08	0.01	1	0.941	1.01
F0-Ringer×F1-LPS	<0.01	0.08	<0.01	1	0.958	1.00
F0-LPS×F1-LPS	0.10	0.08	1.68	1	0.195	1.11
T×F1-treatment			45.26	2	0.031
T×F1-Ringer	−0.03	0.02	2.22	1	0.136	0.97
T×F1-LPS	−0.04	0.02	6.93	1	0.008	0.96

^aParental (F₀) or offspring (F₁) immune treatments, Ringer (5 μl); LPS (5 μl, 0.5 mg ml⁻¹); T, time covariate (in weeks).

^bb=regression coefficient of overall survival function for variable.

^cStandard error of regression coefficient.

^dWald statistic for variable.

^eSignificance level for Wald statistic. Values p≤0.05 are given in bold.

^fOdds ratio of survival for variable relative to control (=exp(b)).

^gResult that used the Ringer-treatment as reference category in the model.