Figure 7.

Proposed model of action of FapR. The figure shows the repressed (operator-bound, left) and derepressed (malonyl-CoA-bound, right) states of FapR. In each case, molecular surfaces represent the experimental X-ray structures. The DBDs (gray cylinders) are modeled on the MecI/BlaI repressor family (Garcia-Castellanos et al, 2003). The proposed α_L–α_L interaction for the repressed state is indeed observed between neighboring dimers in the crystal structure of the FapR_Δ43–malonyl-CoA complex.