Table 1. Levels of human transcript coverage versus extent of conservation in mouse.
Human transcript coveragea,b | Fraction of considered human splice junctions that are conserved in mousec | ||
---|---|---|---|
All splice junctions (constitutive and alternative) | Constitutive splice junctions | Alternative splice junctions | |
1 | 0.173 | 0.492 | 0.082 |
2 | 0.366 | 0.594 | 0.165 |
3 | 0.526 | 0.664 | 0.337 |
4 | 0.574 | 0.710 | 0.327 |
5–9 | 0.629 | 0.723 | 0.326 |
≥10 | 0.749 | 0.779 | 0.530 |
aOnly 19% of constitutive splice junctions as opposed to 64% of alternative splice junctions have transcript coverage of 1. As high as 51% of constitutive splice junctions as opposed to 10% of alternative splice junctions have a high transcript coverage of ≥5.
bThe extents of conservation of splice junctions, irrespective of the human transcript coverage, is 41% for all 2932 (constitutive and alternative) splice junctions, 67% for the 1440 constitutive splice junctions, and 15% for the 1492 alternative splice junctions.
cThe extent of conservation increases with the increasing human transcript coverage, irrespective of the type of splice junction (constitutive or alternative).