Figure 2.

Residues involved in LTag–p53 interactions. (A) A ribbon illustration of a monomeric LTag–p53 complex taken from the hexameric structure. The boxes indicate the two regions at the interface between p53 (in yellow) and LTag (in green). (B) The close-up view of the interactions in box 1, showing that p53 residues P177 and H178 make van der Waals contacts with LTag residues A586 and V597, respectively, and p53 R181 bonds with LTag Q593. (C) The LTag–p53 interface around the zinc motif of p53. The zinc atom is between the two boxed regions, bridging and stabilizing p53 surface loops that contact LTag. (D,E) The close-up views of the detailed interactions within. D shows a hydrophobic pocket formed by LTag residues L609, W581, Y582, and Y612, with which p53 M246 interacts. E shows that four bonds form between p53 N288, R273, N239, and R280 with LTag residues Q613, D604, E601, and D402, respectively.