Table V. Correlation between the presence of the H-bond between loops B and C and the potency in wild-type and mutant receptors.
|
% H-bonda |
Potency |
---|---|---|
α4β2 | 42 | High |
α7 | 0 | Low |
α7 G152K | 14 | High |
α7 P193I | 0 | High |
α7 G152K/P193I | 20 | High |
α1β1γδ | 0 | Low |
α1β1γδ α1G153S | 39 | High |
aDetermined as the number of recorded conformers that displayed the H-bond relative to the total number of recorded conformers.