Fig. 2. CTG repeat size variations following transgene transmission between parent and offspring carrying different Msh2 genotypes. The upper genotype indicates parental Msh2 status and the lower genotype indicates that of the offspring. + is the wild-type allele and – is the mutant allele. In each column, the left bar corresponds to male transmissions and the right bar to female transmissions. The frequencies of expansions (Exp.) and contractions (Cont.) are indicated for each transmission. n is the number of transmissions analyzed.