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Model of E2FC Action.
(A) E2FC negatively regulates the G1/S phase and positively regulates, when the conditions are optimal, the entry of some cells in the endoreplication program.
(B) When E2FC is overexpressed, there is stronger G1/S inhibition and many of the dividing cells are forced into the endoreplication program, thus reducing the proportion of cells undergoing the G2/M transition.
