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Proteasome inhibitors stimulate bone formation in murine calvariae. (a–e) Histological sections of calvariae from mice injected over the right side of the calvarium three times a day for 5 days with either (a and e) vehicle control, (b) PS1 at 0.1 mg/kg/day, (c) PS1 at 1 mg/kg/day, (d) PS1 at 5 mg/kg/day, (f) epoxomicin at 0.05 mg/kg/day, (g) epoxomicin at 0.1 mg/kg/day, and (h) epoxomicin at 0.5 mg/kg/day. Arrows indicate width of new bone.
