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CCR5 internalization induced by RANTES and RANTES variants. P2 and AOP-RANTES induce dose-dependent receptor down-modulation. Steady-state levels of surface CCR5 on the indicated cells (HEK- or CHO-CCR5) were measured by flow cytometry after incubation with chemokines. Levels are expressed as percentages of that of the control (medium, no chemokine). These data are representative of three independent experiments performed under identical conditions.
