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Increased selectivity of selected mutant chemokines P1 and P2 for CCR5. Cytosolic calcium-dependent fluorescence changes in response to various concentrations of RANTES (▪), P1 (•), and P2 (○) via CCR5 (A), CCR3 (B), and CCR1 (C) were determined by using stably transfected HEK cells that had been loaded with Fluo-4 dye.
