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Inhibition of BVDV replication by compound-1453. (A) Structure of compound-1453. (B) Plates (96-well) of MDBK cells were infected with BVDV (500 PFU/well) or mock infected in the presence of various concentrations of compound-1453; 4 days later, percentages of protection (closed circles) and cytotoxicity (open circles) were calculated through the MTT-based colorimetric assay.
