TABLE 2.

Effect of multiple LTβR-Ig treatments on susceptibility to scrapie^a

No. of dosesb	hu-Ig		LTβR-Ig
	Incidence	Mean incubation period (days) ± SE	Incidence	Mean incubation period (days) ± SE
1	8/8	296 ± 8	5/7	341 ± 22, 2× > 500
2	8/8	305 ± 7	5/8	351 ± 12, 3× > 510c
3	9/9	312 ± 13	7/9	369 ± 26, 2× > 510d

^aSee Table 1, footnote a.

^bMice were given a single i.p. injection (100 μg) of LTβR-Ig or hu-Ig (as a control) 3 days before i.p. inoculation with scrapie. Mice were then given injections of LTβR-Ig or hu-Ig (100 μg) at 21-days intervals after scrapie inoculation.

^cOne mouse was killed 414 days after inoculation. No histopathological signs of scrapie were detected in the brain (data not shown).

^dTwo mice were killed 320 and 336 days after inoculation. No histopathological signs of scrapie were detected in their brains (data not shown).