TABLE 1.

Experimentally determined midpoint-folding transitions for RNase A and SNase

Protein	Description	Temperature [K]	pH	Folding pressure [bar]	Reference
Ribonuclease A	WT	313	5.5	5930	(64)
	F46V	313	5.5	1740
	F46E	283	5.5	1540
	F46K	283	5.5	1020
Staphylococcal nuclease	WT	294	5.5	2047	(54)
	V66A	294	5.5	890
	WT	294	4.5	1090	(65)
	A69T+A90S	294	7.0	80

Mutations are described as: original amino-acid residue; residue location; and mutated amino-acid residue. For instance, the mutation of the 46th residue of a chain from Phe to Val is represented as F46V.