Table 5.
Odds Ratios for Associations of Parental and Child Characteristics With Antigen-Specific Lymphocyte Proliferation
| Variables | OR (95% CI) |
|---|---|
| Bla g 2 SI (n = 356, SI >2 in 85 participants)* | |
| Maternal history of asthma | |
| Yes | 1.09 (0.50–2.43) |
| No (referent) | 1.00 |
| Maternal smoking during pregnancy | |
| Yes | 18.26 (3.53–94.42) |
| No (referent) | 1.00 |
| Missing | 0.71 (0.30–1.68) |
| Maternal BMI | 1.01 (0.96–1.06) |
| Maternal weight gain during pregnancy† | |
| Inadequate | 2.27 (1.00–5.15) |
| Adequate (referent) | 1.00 |
| Excessive | 2.59 (1.34–5.00) |
| Neonate race/ethnicity | |
| White (referent) | 1.00 |
| Black | 2.97 (1.49–5.92) |
| Hispanic | 1.75 (0.65–4.69) |
| Asian | 2.37 (0.80–7.00) |
| 5-Minute Apgar score | |
| ≥8 (referent) | 1.00 |
| <8 | 6.09 (1.23–30.09) |
| Der f 1 SI (n = 356, SI >2 in 139 participants)* | |
| Maternal history of asthma | |
| Yes | 0.86 (0.42–1.73) |
| No | 1.00 |
| Maternal smoking (during pregnancy) | |
| Yes | 6.79 (1.39–33.29) |
| No (referent) | 1.00 |
| Missing | 0.52 (0.24–1.12) |
| Maternal BMI | 1.01 (0.97–1.06) |
| Maternal weight gain during pregnancy† | |
| Inadequate | 1.16 (0.59–2.28) |
| Adequate (referent) | 1.00 |
| Excessive | 1.41 (0.84–2.37) |
| Neonate race/ethnicity | |
| White (referent) | 1.00 |
| Black | 2.73 (1.46–5.11) |
| Hispanic | 1.86 (0.80–4.33) |
| Asian | 1.49 (0.60–3.75) |
| 5-Minute Apgar score | |
| ≥8 (referent) | 1.00 |
| <8 | 2.85 (0.61–13.3) |
| Phytohemagglutinin SI (n = 407, SI >40.1 in 203 participants)‡ | |
| Maternal history of asthma | |
| Yes | 1.04 (0.56–1.92) |
| No | 1.00 |
| Maternal smoking (during pregnancy) | |
| Yes | 1.71 (0.47–6.27) |
| No (referent) | 1.00 |
| Missing | 1.26 (0.64–2.50) |
| Maternal BMI | 1.05 (1.01–1.10) |
| Maternal weight gain during pregnancy† | |
| Inadequate | 1.44 (0.77–2.68) |
| Adequate (referent) | 1.00 |
| Excessive | 0.94 (0.59–1.51) |
| Neonate race/ethnicity | |
| White (referent) | 1.00 |
| Black | 1.80 (1.01–3.20) |
| Hispanic | 0.61 (0.27–1.36) |
| Asian | 1.47 (0.64–3.36) |
| 5-Minute Apgar score | |
| ≥8 (referent) | 1.00 |
| <8 | 0.76 (0.22–2.62) |
Abbreviation: BMI, body mass index (calculated as weight in kilograms divided by the square of height in meters); CI, confidence interval; OR, odds ratio; SI, ratio of mean counts per minute of stimulated lymphocytes divided by mean counts per minute of unstimulated lymphocytes.
*
Dichotomized at 2.
†
Defined according to Institute of Medicine guidelines,22 using prepregnancy BMI and total weight gain during pregnancy (see text).
‡
Dichotomized at median.