Table 2.
Incidence of anomalies caused by TCDD in fetuses from heterozygous hAHR parents
| Genotype of fetuses | TCDD dose, μg/kg | Dams examined, n | Fetuses examined, n | Fetuses with
|
||||
|---|---|---|---|---|---|---|---|---|
| Cleft palate
|
Hydronephrosis
|
|||||||
| n | %* | n | %* | Severity: 0–3.0 | ||||
| Ahrb-1/b-1 | 40 | 9 | 9 | 100 | 9 | 100.0 | 2.47 ± 0.14† | |
| Hetero-hAHR | 40 | 7 | 25 | 12 | 48 | 22 | 88.0 | 2.46 ± 0.13 |
| Homo-hAHR | 40 | 12 | 0 | 0 | 8 | 66.6 | 1.17 ± 0.01† | |
*
Percentage of fetuses with each anomaly out of all fetuses examined.
†
Significant difference between homozygous hAHR and Ahrb-1/b-1 fetuses (P < 0.0001).