Figure 1.

Physical map of the D6S1581–D6S1008 genomic interval. (a) All microsatellite markers and bacterial artificial chromosome/P1 bacteriophage artificial chromosome clone sequences were obtained from the National Center for Biotechnology Information database. The positions and alignment of known genes identified in this region and the markers used for LOH analysis are indicated. The Parkin genomic structure according to ref. 32 is also shown (Lower). (b) Summary of allelic loss in six breast and four ovarian malignant tumors with partial deletions at 6q25–q27. Each vertical line represents a single case and black, gray, and white circles represent LOH, retention of heterozygosity, and noninformative results, respectively. The shared minimal region of loss among informative cases is indicated on the right side between markers D6S1599 and D6S305.