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IL-17 is required for antigen-specific T cell priming. Proliferative responses of DO11.10 T cells against the ovalbumin 323–339 peptide in the presence of APCs from wild-type or IL-1Ra−/− mice were assessed by measuring the incorporation of [3H]thymidine after 3 days of culture. Effects of IL-17 deficiency were evaluated by using IL-17−/− DO11.10 T cells and IL-1Ra−/− APCs. Data shows an average ± SD of three wells. These results were reproducible in two independent experiments.
