Skip to main content
. 2003 Apr 29;100(10):5986–5990. doi: 10.1073/pnas.1035999100

Figure 5.

Figure 5

IL-1 could not directly induce IL-17 in CD4+ T cells. (A) IL-17 could not induce CD40L and OX40 expression on CD4+ T cells. Splenic CD4+ T cells from wild-type mice were stimulated with plate-coated anti-mouse CD3 mAb (1 μg/ml) with or without rIL-17 for 24 (for CD40L expression) and 72 h (for OX40 expression). These results were reproducible in two independent experiments. (B) Splenic CD4+ T cells from wild-type mice were stimulated with or without rIL-1α together with plate-coated anti-mouse CD3 mAb for 24, 48, and 72 h. Then, IL-17 levels in culture supernatants were determined by ELISA. Data show a pooled supernatant from three wells. These results were reproducible in two independent experiments.