Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic of the Role of Hippocalcin in Synaptically Evoked AMPAR Internalization
Ca2+ entry via NMDARs activates the hippocalcin myristyl switch and stimulates binding to β-adaptin of the AP2 complex, causing translocation of AP2-hippocalcin to the plasma membrane (A). AP2 binds to the GluR2 subunit of AMPARs and recruits clathrin (B). Clathrin displaces hippocalcin prior to endocytosis, after which AMPAR internalization occurs (C).
