Figure 1.

Identification of A138G polymorphism in exon 6 of CD45. (A) An A → G transversion in position 138 of exon 6 was identified. Shown are examples of a common variant homozygote allele, a heterozygote, and a homozygote. The changed bases are boxed. (B) Schematic structure of exon 6, showing the relative position of the A138G mutation, which is 7 bp from the 3′ end of exon 6. The sequence of exon 6 is shown in a one-letter amino acid code, and the potential glycosylation sites are indicated by arrows. The mutation leads to the amino acid change 47T → A in the coded CD45RC domain, shown in red.