Table 2.
nAb against second-generation escape mutants
| Mice | Virus
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| V1.1 | V1.2 | V2.2 | V2.3 | V3.2 | V3.7 | V3.9 | V4.1 | V4.5 | V6.3 | |
| V1 infected; cleared | <1 | <1 | 2–3 | ≥4 | 2–3 | 2–3 | 2–3 | <1 | 2–3 | 2–3 |
| V1 infected; V1.1–4 emerged | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 |
| V2 infected; cleared | ≥4 | ≥4 | ≥4 | <1 | <1 | 2–3 | <1 | 2–3 | <1 | ≥4 |
| V2 infected; V2.1–3 emerged | <1 | 2–3 | <1 | <1 | <1 | <1 | <1 | <1 | ≥4 | <1 |
| V3 infected; V3.1–6 emerged | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 |
| V3 infected; V3.7–9 emerged | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 |
| V4 infected; V4.1–3 emerged | ≥4 | ≥4 | 2–3 | 2–3 | ≥4 | ≥4 | 2–3 | <1 | ≥4 | ≥4 |
| V4 infected; V4.4–6 emerged | <1 | <1 | <1 | <1 | <1 | <1 | <1 | 2–3 | <1 | <1 |
| V5 infected; cleared | 2–3 | <1 | <1 | <1 | ≥4 | ≥4 | 2–3 | <1 | ≥4 | ≥4 |
| V6 infected; cleared | <1 | 2–3 | <1 | <1 | <1 | ≥4 | <1 | 2–3 | 2–3 | <1 |
| V6 infected; V6.1–3 emerged | 2–3 | <1 | <1 | <1 | <1 | 2–3 | 2–3 | <1 | <1 | <1 |
| M1 | <1 | <1 | <1 | <1 | <1 | <1 | 2–3 | 2–3 | <1 | ≥4 |
| M2 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 |
| M3 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 |
| M4 | <1 | 2–3 | <1 | <1 | <1 | ≥4 | <1 | <1 | <1 | <1 |
| M5 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 |
| M6 | 2–3 | 2–3 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 |
| M7 | ≥4 | ≥4 | 2–3 | ≥4 | 2–3 | 2–3 | 2–3 | 2–3 | ≥4 | ≥4 |
| M8 | 2–3 | 2–3 | 2–3 | 2–3 | 2–3 | ≥4 | 2–3 | ≥4 | <1 | ≥4 |
Highest titers at any tested time point are shown. Titers are differentiated between nonneutralizing (<1), low neutralizing (2–3; 1/40–1/80), and high neutralizing (≥4; ≥1/160) activity.