Table 3.

Summary of mutations identified within the bounds of the coding region of the TLR2 gene

TLR2	Meningococcal disease	Normal controls	P*
Missense	8	13	0.132
Synonymous	136	105	0.972
Diploid coverage†	440.9 kb (187.2 CE)	336.0 kb (142.7 CE)
Number of subjects	102	104

Details concerning all mutations are given in Table 4. 

^*P value refers to the difference between meningococcal and normal groups collected in the United Kingdom. χ² test, two-tailed. Calculations are performed with respect to diploid coverage values, i.e., the number of coding substitutions per number of nucleotides of coding sequence examined. 

^† Total coding sequence acquired on both strands, given as kb or CE.