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. 2003 Apr 29;100(10):6087–6092. doi: 10.1073/pnas.1031632100

Figure 2.

Figure 2

TUDCA reduces apoptosis in the ICH hemisphere. (A) Rare TUNEL-positive cells were seen in the contralateral hemisphere with vehicle (a) and 100 mg/kg of bw TUDCA given 1 h before ICH (b). A marked increase was detectable in the ICH hemisphere of vehicle animals (c), and at higher magnification (e). TUDCA significantly reduced TUNEL reactivity (d), and at higher magnification (f). (Original magnification, ×200.) (B) Greater numbers of apoptotic cells were observed in vehicle rats than in TUDCA. Data are presented as the mean ± SEM (n = 5 animals per group). (C) Caspase activity was significantly increased in the vehicle controls and reduced with TUDCA. Data are the mean ± SEM (n = 5 animals per group). *, P < 0.05; §, P < 0.01 from vehicle.