Figure 4.

TUDCA improves neurological function after ICH. (A) Rotational bias in rats with unilateral hemorrhage of the striatum was induced by apomorphine and evaluated in rats given TUDCA at 100 mg/kg of bw (black bars) or saline (white bars) at 1, 3, or 6 h after ICH. TUDCA animals in all groups displayed statistically significant reductions in rotational bias in comparison with their temporal control groups. (B) Limb placement in rats with unilateral hemorrhagic striatal injury was evaluated in rats given TUDCA (black bars) or saline (white bars) at 1, 3, or 6 h. TUDCA rats treated at 1 and 3 h exhibited significant improvements in limb placement scores. Data are presented as the mean ± SEM (n = 3–7 animals per group). *, P < 0.05 from respective controls.