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. 2003 Apr 29;100(10):6087–6092. doi: 10.1073/pnas.1031632100

Figure 5.

Figure 5

TUDCA reduces NF-κB activation in ICH. (A) Striatal sections showing activation of NF-κB/p65 2 days after ICH. Immunoreactive NF-κB was clearly detectable in vehicle controls (a) but significantly reduced with 100 mg/kg of bw TUDCA given 1 h before ICH (b). (B) Representative immunoblot of p65 NF-κB subunit and IκBα and quantitation of changes in NF-κB/IκBα protein complex. Total protein extracts were subjected to SDS/PAGE, and the blots probed with antibodies to NF-κB/p65 and IκBα. TUDCA reduced the changes in NF-κB/IκBα protein expression from vehicle controls. Data are expressed as the mean ± SEM (n = 3–5 animals per group). *, P < 0.05 from vehicle.