Figure 4.

Nifedipine action is independent of calcium. (A) Sample current traces of three different neurons, treated with Cd²⁺, thapsigargin, or BAPTA-AM (Upper) and the effect of nifedipine on these treated cells (Lower). (B) Sample evoked EPSCs of three different neurons, showing the effect of Cd²⁺, thapsigargin, or BAPTA-AM. (C) Summary of the effect of Cd²⁺, thapsigargin, or BAPTA-AM on nifedipine-induced mEPSC frequency. In these cells, nifedipine was applied first. (D) Summary of the effect of Cd²⁺, thapsigargin, or BAPTA-AM on evoked EPSC amplitude. *, P < 0.05 vs. control. Thaps, thapsigargin; Nifed, nifedipine.