N-back performance based on genotype and drug condition. *, AMP caused a significant decrease in performance on the 3-back task in met/met individuals (P < 0.05; Duncan post hoc test). There was no significant difference in serum AMP levels across the three genotypes (mean ± SEM; val/val = 54 ± 3.6 ng/ml, val/met = 53 ± 2.9 ng/ml, and met/met = 56 ± 2.7 ng/ml; ANOVA F(2,22) = 0.27, P = 0.8) and no effect of genotype on any of the clinical variables. Further details on clinical variables are available in Supporting Text.