Table 1.
Characteristics of diabetic participants in the Health ABC study of older well-functioning adults
| Variable | Non-TZD users | TZD users |
|---|---|---|
| N = 597 | N = 69 | |
| Gender (% women) | 46.6 | 46.4 |
| Race (% Black) | 48.2 | 53.6 |
| Age at baseline | 73.6± 2.8 | 73.2± 2.5 |
| Baseline weight (kg) | 81.2± 15.1 | 82.7 ±14.5 |
| 4 year weight change (kg) | -1.4± 5.5 | 0.5± 6.0a |
| A1C (%) - Baseline (BL) | 7.3± 1.5 | 8.4± 1.6a |
| 3 yrs after BL | 6.7± 1.4 | 7.6± 1.5a |
| 5 yrs after BL | 6.6± 1.2 | 7.1± 0.9a |
| Duration of diabetes (yrs) | 7.1± 11.3 | 9.5± 10.7 |
| Glomerular filtration rateb (mL/min per 1.73 m2) | 73.0± 17.5 | 76.9± 20.2 |
| Baseline BMD: | ||
| Whole body BMD (g/cm2) | 1.12± 0.14 | 1.14± 0.15 |
| Lumbar spine BMD c(g/cm2) | 1.08± 0.22 | 1.11±0.23 |
| Total hip BMD (g/cm2) | 0.94± 0.17 | 0.96±0.18 |
| Femoral±neck BMD (g/cm2) | 0.79±0.14 | 0.79±0.15 |
| Trochanter BMD (g/cm2) | 0.73±0.15 | 0.75±0.15 |
| Medication Use at Baseline: | ||
| Insulin (% Yes) | 13.4 | 18.8 |
| Metformin (% Yes) | 7.1 | 14.5a |
| Sulfonylurea (% Yes) | 29.2 | 55.1a |
| Oral estrogen (% Yes) (women only) | 20.5 | 15.6 |
| Oral steroid (% Yes) | 2.7 | 0.0 |
| Any osteoporosis drugs (% Yes) | 2.7 | 1.4 |
| Thiazide diuretics (% Yes) | 22.9 | 15.9 |
| Statin (% Yes) | 14.3 | 29.0a |
| Calcium supplement (% Yes) | 13.9 | 13.0 |
| Vitamin D supplement (% Yes) | 6.2 | 2.9 |
Data are mean ±standard deviation or %
a
p <0.05, comparing non-TZD and TZD users.
b
Estimated with abbreviated Modification of Diet in Renal Disease (MDRD) equation
c
Obtained from lumbar spine subregion of whole body DXA scans