Table 3.
Additional annualized percent change in BMD per year of TZD use
| WOMEN |
MEN |
|||||
|---|---|---|---|---|---|---|
| Model | Estimate (% change) | (95% CI) | p-value | Estimate (% change) | (95% CI) | p-value |
| Whole Body | ||||||
| Adjusted for age, race | -0.67 | (-1.03, -0.30) | <0.001 | 0.00 | (-0.32, 0.31) | 0.987 |
| Multivariablea | -0.61 | (-1.02,-0.21) | 0.003 | 0.04 | (-0.30,0.39) | 0.810 |
| Lumbar Spineb | ||||||
| Adjusted for age, race | -1.14 | (-1.90,-0.37) | 0.004 | -0.19 | (-0.96,0.58) | 0.627 |
| Multivariablea | -1.23 | (-2.06,-0.40) | 0.004 | -0.25 | (-1.10,0.60) | 0.567 |
| Femoral Neck | ||||||
| Adjusted for age, race | -0.26 | (-0.86,0.34) | 0.391 | 0.09 | (-0.39, 0.56) | 0.713 |
| Multivariablea | -0.32 | (-0.94, 0.29) | 0.303 | -0.05 | (-0.54, 0.44) | 0.843 |
| Trochanter | ||||||
| Adjusted for age, race | -0.50 | (-1.02, 0.03) | 0.063 | -0.17 | (-0.57, 0.23) | 0.414 |
| Multivariablea | -0.65 | (-1.18, -0.12) | 0.016 | -0.32 | (-0.72, 0.09) | 0.124 |
a
Age, race, baseline BMD, baseline weight, weight change, average A1C, insulin, metformin, sulfonylureas, other hypoglycemic medications, diabetes duration, GFR, vitamin D supplements, calcium supplements, oral steroids, osteoporosis drugs (bisphophonates, calcitonin, raloxifene), thiazide diuretics, statins and oral estrogen (women only).
b
Obtained from lumbar spine subregion of whole body DXA scans