TABLE 1.
In vitro activities of daptomycin and other antimicrobial agents against 98 MRSA strains isolated in The Netherlands
| Antibiotic | MIC (mg/liter)
|
% Susceptibilitya
|
|||
|---|---|---|---|---|---|
| Range | MIC50 | MIC90 | S | R | |
| Daptomycin | 0.125-1 | 0.38 | 0.75 | 100 | 0 |
| Oxacillin | 0.19-≥256 | 256 | 256 | 0 | 100b |
| Vancomycinc | 2-6 | 3.0 | 4.0 | ||
| Teicoplaninc | 1-16 | 3.0 | 12.0 | ||
| Gentamicin | 0.38-≥256 | 1.0 | 256 | 54.1 | 43.9 |
| Cotrimoxazole | 0.032-≥32 | 0.094 | 32.0 | 87.8 | 11.2 |
| Ciprofloxacin | 0.25-≥32 | 32.0 | 32.0 | 24.5 | 72.4 |
| Erythromycin | 0.19-≥256 | 256 | 256 | 26.5 | 72.4 |
| Clindamycin | 0.047-≥256 | 0.19 | 256 | 58.2 | 41.8 |
| Rifampin | 0.004-≥32 | 0.012 | 32.0 | 69.4 | 21.3 |
a
S, sensitive; R, resistant.
b
Identification as S. aureus and methicillin resistance were determined by duplex PCR for the mecA gene and coagulase gene (19).
c
The Etest system with a large inoculum and 48 h of incubation was used.