TABLE 1.
Pharmacokinetic parameters after administration of 400 mg voriconazole as a single oral dose in a CYP2C9*2/CYP2C9*2 patient (CYP2C19 homozygous EM) compared to results for eight CYP2C9 EM healthy volunteers (CYP2C19 homozygous EM)
| Patient or group | AUC0-∞ (μg · h/ml) | Vz (liters/kg) | Cl/F (ml/min) | Cl/F (ml/min/kg) | t1/2 (h) |
|---|---|---|---|---|---|
| CYP2C9*2*2 subject | 16.61 | 3.51 | 401 | 6.68 | 6.05 |
| CYP2C9 EM subjectsa | 16.52 ± 7.21 | 4.38 ± 1.73 | 463 ± 168 | 6.34 ± 2.47 | 8.11 ± 1.35 |
a
Results for the CYP2C9 EM group are expressed as means ± standard deviations.