TABLE 1.
Point estimates and 95% confidence intervals of the fixed effects and goodness of fit for the two regimens from pooled and mixed-effects fits using the whole data set (SHT n = 54, SHRZ n = 46)
| Regimen | A (log10 CFU) | α (log10 CFU/ml/day) | B (log10 CFU) | β (log10 CFU/ml/day) | AICa | LRb test |
|---|---|---|---|---|---|---|
| SHT | ||||||
| Monoexponential | 6.081 (5.851-6.311)c | 0.102 (0.086-0.122) | 769.4 | |||
| Biexponential | 6.633 (6.282-6.984) | 0.621 (0.241-1.132) | 5.380 (4.916-5.844) | 0.066 (0.045-0.099) | 751.9 | <0.0001 |
| Biexponential mixed effects | 6.650 (6.264-7.037) | 0.881 (0.651-1.191) | 5.463 (5.114-5.812) | 0.076 (0.060-0.095) | 688.6 | <0.001 |
| SHRZ | ||||||
| Monoexponential | 6.397 (6.148-6.647) | 0.146 (0.128-0.167) | 622.2 | |||
| Biexponential | 6.845 (6.509-7.180) | 0.456 (0.243-0.858) | 5.472 (4.868-6.075) | 0.100 (0.072-0.140) | 606.4 | <0.0001 |
| Biexponential mixed effects | 6.834 (6.509-7.159) | 0.519 (0.409-0.658) | 5.307 (4.824-5.790) | 0.094 (0.079-0.113) | 526.7 | <0.001 |
a
AIC, Akaike information criterion.
b
LR, likelihood ratio.
c
Values in parentheses are 95% confidence intervals.