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Effects of receptor occupancy on channel deactivation. Using the HKIR3.1/3.2/A1 cell line we studied the effects of agonist concentration on channel-deactivation rates. (A) Representative examples of these experiments with 30 nM and 1 μM NECA. The bar charts that summarize the data obtained from these experiments show that channel deactivation was unaffected by agonist concentration with both the A1 receptor (B) and the GABA-B1b/2 receptor (C). NS, not significant.
