Rational design of 8-(1,1-DMA)-DHS. Chemical structure of the designed flavonoid with (i) ring B branched at position 2, (ii) an oxidized 2,3 bond, (iii) a monolignol unit adjacent to ring B, (iv) hydroxyl groups at positions 3 and 5, (v) a hydrophobic substitution at position 8, and (vi) 1,1-dimethylallyl as the hydrophobic group.