FIG. 8.

Effect of a cocktail of inhibitors on [¹⁴C]miltefosine accumulation. The uptake of [¹⁴C]miltefosine in wild-type and MDR parasites was measured for 1 h in the absence (vertical and horizontal shaded bars, respectively) or presence (gray and black filled bars, respectively) of cocktail 1, as described in Materials and Methods. The data shown are the means and standard errors of three independent experiments, each performed in duplicate, and are expressed as percent [¹⁴C]miltefosine accumulation with respect to the accumulation measured for the control.