TABLE 2.
Details of 27 serologically classical acute primary/secondary and probable acute secondary flavivirus infections when S1 samples were collected on days 1 to 3 after the onset of symptoms
| Day and infection typea | Dengue virus serotypeb | S1 sample
|
S2 sample
|
||||
|---|---|---|---|---|---|---|---|
| Titer (OD at 1/100)c
|
IgM/IgG OD ratio (P or S)d | Titer (OD at 1/100)c
|
IgM/IgG OD ratio (P or S)d | ||||
| IgM | IgG | IgM | IgG | ||||
| 1 | |||||||
| S | — (0.41) | 5.28 (1.34) | 0.31 (S) | — (0.50) | 5.97 (1.44) | 0.35 (S) | |
| S | 4 | — (0.22) | — (0.45) | 0.49 (S) | — (0.53) | 5.75 (1.45) | 0.37 (S) |
| S | 4 | — (0.28) | — (0.53) | 0.53 (S) | 2.88 (0.97) | 5.28 (1.33) | 0.73 (S) |
| S | 4 | — (0.33) | — (0.42) | 0.78 (S) | — (0.38) | 5.82 (1.42) | 0.27 (S) |
| S | 2 | — (0.47) | — (0.60) | 0.78 (S) | 3.50 (1.32) | 5.88 (1.28) | 1.03 (S) |
| S | 4 | — (0.40) | — (0.50) | 0.80 (S) | 2.73 (0.90) | 5.61 (1.35) | 0.67 (S) |
| S | 4 | 2.23 (0.75) | 4.66 (0.94) | 0.80 (S) | 3.26 (1.24) | 6.22 (1.35) | 0.92 (S) |
| S | 4 | — (0.29) | — (0.29) | 1.00 (S) | — (0.64) | 5.83 (1.47) | 0.43 (S) |
| LS | — (0.29) | 2.63 (0.73) | 0.40 (S) | — (0.44) | 3.73 (0.75) | 0.59 (S) | |
| PS | 1 | — (0.55) | — (0.50) | 1.10 (S) | 3.04 (1.03) | 6.16 (1.34) | 0.77 (S) |
| 2 | |||||||
| P | — (0.57) | — (0.18) | 3.17 (P) | 3.05 (1.46) | — (0.66) | 2.21 (P) | |
| S | — (0.45) | 4.25 (0.90) | 0.50 (S) | — (0.69) | 5.18 (1.25) | 0.55 (S) | |
| S | — (0.61) | 3.62 (0.78) | 0.78 (S) | 3.07 (1.06) | 6.23 (1.45) | 0.73 (S) | |
| S | 1 | — (0.36) | — (0.37) | 0.97 (S) | 2.33 (0.74) | 5.82 (1.50) | 0.49 (S) |
| LS | — (0.50) | 2.38 (0.73) | 0.68 (S) | — (0.54) | 4.21 (0.78) | 0.69 (S) | |
| PS | — (0.63) | 3.40 (0.75) | 0.84 (S) | 3.18 (1.17) | 6.43 (1.33) | 0.88 (S) | |
| PS | 4 | — (0.55) | — (0.48) | 1.15 (S) | — (0.66) | 5.44 (1.25) | 0.53 (S) |
| 3 | |||||||
| P | — (0.55) | — (0.15) | 3.67 (P) | 2.88 (1.08) | — (0.47) | 2.30 (P) | |
| S | — (0.38) | 4.61 (1.06) | 0.36 (S) | — (0.52) | 5.76 (1.39) | 0.38 (S) | |
| S | 2 | 2.21 (0.76) | 4.90 (1.16) | 0.66 (S) | 3.97 (1.34) | 6.47 (1.34) | 1.00 (S) |
| S | 2.43 (0.86) | 4.42 (1.04) | 0.83 (S) | 2.92 (1.09) | 5.73 (1.38) | 0.79 (S) | |
| S | 4 | 2.83 (1.18) | 5.18 (1.36) | 0.87 (S) | 3.60 (1.41) | 6.85 (1.45) | 0.97 (S) |
| S | 4 | — (0.61) | — (0.64) | 0.95 (S) | 3.23 (1.23) | 5.65 (1.37) | 0.90 (S) |
| LS | — (0.48) | — (0.60) | 0.80 (S) | — (0.48) | 4.00 (0.75) | 0.64 (S) | |
| PS | 2.72 (0.84) | 6.02 (1.34) | 0.63 (S) | 2.97 (1.01) | 6.65 (1.36) | 0.74 (S) | |
| PS | 4 | — (0.21) | — (0.28) | 0.75 (S) | — (0.34) | 5.73 (1.41) | 0.24 (S) |
| PS | 2 | 2.70 (0.81) | 4.97 (1.07) | 0.76 (S) | 3.28 (1.12) | 6.01 (1.30) | 0.86 (S) |
Infection type classification as acute primary (P), acute secondary (S), low S2 IgG acute secondary (LS), or probable acute secondary (PS) flavivirus infection.
Dengue type 1 (1), type 2 (2), or type 4 (4) viruses isolated.
log10t50 IgM and IgG titers (— indicates <0.72 OD titer threshold) and IgM and IgG ODs at a serum dilution of 1/100 (in parentheses).
IgM/IgG OD ratios and classifications of the S1 and S2 samples as primary (P) or secondary (S) flavivirus infection by concordance of all three discriminatory IgM/IgG OD ratios (≥1.78, 1,40, and 1.20 or <1.78, 1.40, and 1.20) (in parentheses).