TABLE 3.
Details of 10 serologically nonclassical acute primary/secondary and probable acute secondary flavivirus infections when the S1 samples were collected on days 1 to 3 after the onset of symptoms
| Day and infection typea | Dengue virus serotypeb | S1 sample
|
S2 sample
|
||||
|---|---|---|---|---|---|---|---|
| Titer (OD at 1/100)c
|
IgM/IgG OD ratio (P and/or S)d | Titer (OD at 1/100)c
|
IgM/IgG OD ratio (P and/or S)d | ||||
| IgM | IgG | IgM | IgG | ||||
| 1 | |||||||
| *S | 2 | — (0.25) | — (0.18) | 1.39 (S/S/S/P) | 3.20 (1.16) | 6.01 (1.40) | 0.83 (S) |
| *S | 4 | — (0.35) | — (0.25) | 1.40 (S/S/P/P) | 3.51 (1.42) | 5.92 (1.44) | 0.99 (S) |
| *S | 2 | — (0.40) | — (0.25) | 1.60 (S/S/P/P) | 3.83 (1.37) | 6.27 (1.43) | 0.96 (S) |
| *S | 1 | — (0.49) | — (0.28) | 1.75 (S/S/P/P) | 2.96 (1.10) | 5.78 (1.38) | 0.80 (S) |
| *LS | 1 | — (0.28) | — (0.11) | 2.55 (S/P/P/P) | 4.10 (1.44) | 4.38 (1.02) | 1.41 (S/P/P) |
| 2 | |||||||
| *LS | — (0.57) | — (0.28) | 2.04 (S/P/P/P) | — (0.61) | 4.18 (0.79) | 0.77 (S) | |
| *PS | 1 | — (0.68) | — (0.27) | 2.52 (S/P/P/P) | 3.97 (1.40) | 4.93 (1.22) | 1.15 (S) |
| 3 | |||||||
| *P | — (0.48) | — (0.40) | 1.20 (S/S/S/P) | 2.78 (0.90) | — (0.48) | 1.88 (P) | |
| *S | — (0.55) | — (0.35) | 1.57 (S/S/P/P) | 3.24 (1.23) | 5.13 (1.32) | 0.93 (S) | |
| *PS | 2 | 2.70 (0.91) | — (0.39) | 2.33 (S/P/P/P) | 3.63 (1.42) | 5.70 (1.45) | 0.98 (S) |
Infection type classification as high S1 IgG acute primary (*P), high S1 IgM acute secondary(*S), high S1 IgM and low S2 IgG acute secondary(*LS), or high S1 IgM probable acute secondary(*PS) flavivirus infection.
Dengue type 1 (1), type 2 (2), or type 4 (4) viruses isolated.
log10t50 IgM and IgG titers (— indicates <0.72 OD titer threshold) and IgM and IgG ODs of S1 and S2 sera at a 1/100 dilution (in parentheses).
IgM/IgG OD ratios and classifications of the S1 and S2 samples as acute primary (P) and/or secondary (S) flavivirus infection using the ≥2.60, 1.78, 1.40, and 1.20 or <2.60, 1.78, 1.40, and 1.20 discriminatory IgM/IgG OD ratios on the patients' S1 samples (in parentheses) and the ≥1.78, 1.40, and 1.20 or <1.78, 1.40, and 1.20 discriminatory IgM/IgG OD ratios on the patients' S2 samples (in parentheses). A single P or S for the patients' S2 samples indicates concordance between the three discriminatory IgM/IgG OD ratios.