TABLE 2.
Effects of intragastric administration of carbonate buffer, L. salivarius Ls-33(pNZYR), L. plantarum Lp-115(pNZYR), L. acidophilus NCFM(pNZYR), and L. paracasei YS8866441 on healthy micea
| Buffer or strain | No. of mice | Activity score ± SEM | % Variation in wt (day 7-day 1) ± SEM | Colon inflammation | LAB translocation in different organsb | MPO (IU) ± SEMc |
|---|---|---|---|---|---|---|
| NaHCO3 | 5 | 3 ± 0 | 4.4 ± 2 | No | ND | 0.011 ± 0.0017** |
| Ls-33 | 5 | 3 ± 0 | 3.4 ± 2.6 | No | No | 0.017 ± 0.0022** |
| Lp-115 | 5 | 3 ± 0 | 2.7 ± 2.3 | No | No | 0.018 ± 0.0026** |
| NCFM | 5 | 3 ± 0 | 2.4 ± 1 | No | No | 0.014 ± 0.0003** |
| YS8866441 | 5 | 3 ± 0 | 6.6 ± 5.9 | No | No | 0.014 ± 0.0003** |
| TNBS controld | 5 | ND | −11.3 ± 4.5 | Yes | ND | 0.55 ± 0.032 |
a
One TNBS-positive control group (120 mg/kg) was added to the study (mice received phosphate buffer instead of bacteria and received TNBS).Values are means ± SEM. ND, not determined.
b
Detection level in MLN, spleen, liver, and kidneys, ≥1 CFU/organ.
c
Expressed in international units. **, differences were considered significant at a P value of ≤0.01 compared to the TNBS control group.
d
Mean Wallace score, 5 ± 0.9.