TABLE 1.

SPR analysis of human and murine chemokines binding to EVM1^a

Chemokine	ka (106) (M−1s−1)	kd (10−3) (s−1)	KD (nM)	t1/2 (s)
hCCL2	3.2 ± 0.6	66 ± 7	20 ± 4	11
mCCL2	21 ± 5	29 ± 7	1.4 ± 0.5	24
hCCL3	12 ± 4	0.34 ± 0.06	0.029 ± 0.011	2,039
mCCL3	12 ± 1	1.4 ± 0.1	0.121 ± 0.015	495
hCCL5	23 ± 9	5 ± 3	0.230 ± 0.170	139
mCCL5	0.53 ± 0.02	3.3 ± 0.2	6.3 ± 0.5	210

^aValues for k_a, k_d, and K_D are means ± standard deviations. K_D = k_d/k_a; t_1/2 = 0.693/k_d.