FIG. 1.

Functional map of MT and ST. A linear map of the 421- and 195-amino-acid MT and ST proteins is shown. The landmarks shown are the positions of the MT and ST splice sites; the J-domain and the PP2A and src binding domains; the carboxy-terminal hydrophobic membrane insertion domain; the pS257 binding site for 14-3-3 protein; the positions of the three major tyrosines (underlined), Y250, Y315, and Y322, and their connections to downstream signaling intermediates; and the positions of the three minor tyrosines (dashed underline), Y258, Y288, and Y297.