TABLE 3.
Effect of stable LT expression on genome amplification with mutant infectiona
| Virus | Relative amplification ratio
|
||
|---|---|---|---|
| LT-NIH
|
NIH, 48 hpi | ||
| 24 hpi | 48 hpi | ||
| Wild type | 1 | 1 | 1 |
| MT-Ter | 1.3 | 0.8 | 0.6 |
| Y6F | 0.3 | 0.2 | 0.2 |
| A185 | 0.5 | 0.4 | 0.04 |
a
NIH 3T3 and LT-NIH cells were infected with the mutants listed, under the conditions described in the legend to Fig. 2. Samples were collected at 24 hpi and 48 hpi and analyzed by Southern blotting as described for Fig. 7. Relative amplification ratios (WT/mutant) were computed as described in footnote a of Table 2.