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(a) X-ray structure of wt TTR (PDBfile 1F41) obtained at 1.5-Å resolution, showing the four monomers. (b) Secondary-structure analysis of wt TTR by FTIR. Curve fitting of the deconvoluted amide I′ band of wt TTR (37°C, pD 7.5) with eight Gauss-Lorentz functions: 1and 8, nonnative, aggregated β-sheets; 2 and 3, turns; 4, α-helices; 5, random coil; and 6 and 7, β-sheets.
