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. 2006 Aug;80(16):7799–7806. doi: 10.1128/JVI.00318-06

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Copyright © 2006, American Society for Microbiology

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FIG. 3. — In vivo protection against NL199 challenge. Golden Syrian hamsters were injected 24 h prior to intranasal challenge with NL199 with different doses of MAb 234 (solid circles), MAb 338 (solid triangles), or with BSA (solid squares). Animals were bled prior to challenge to determine the levels of serum antibodies present at time of challenge. At 4 days postinfection, lungs (panel A) and nasal turbinates (panel B) were harvested, and virus titers were determined as described in Materials and Methods. Limit of detection (LOD) for the viral titers was 1.2 log/g tissue. For MAb quantification, animal serum samples were diluted 1:100 and 1:500 (panel C). The limit of quantitation (LOQ) for this assay as performed was 0.1 μg MAb/ml serum. P values for MAb 234 were <0.0001, <0.0001, 0.0016, and 0.325 for doses of 3 mg/kg, 1 mg/kg, 0.3 mg/kg, and 0.1 mg/kg, respectively. P values for MAb 338 were <0.0001, <0.0001, <0.0001, and 0.0064 for doses of 3.0 mg/kg, 1.0 mg/kg, 0.3 mg/kg, and 0.1 mg/kg, respectively. Nasal turbinate P values of statistical significance were 0.0006 () and <0.0001 (#). IgG, immunoglobulin G.

Inline graphic — In vivo protection against NL199 challenge. Golden Syrian hamsters were injected 24 h prior to intranasal challenge with NL199 with different doses of MAb 234 (solid circles), MAb 338 (solid triangles), or with BSA (solid squares). Animals were bled prior to challenge to determine the levels of serum antibodies present at time of challenge. At 4 days postinfection, lungs (panel A) and nasal turbinates (panel B) were harvested, and virus titers were determined as described in Materials and Methods. Limit of detection (LOD) for the viral titers was 1.2 log/g tissue. For MAb quantification, animal serum samples were diluted 1:100 and 1:500 (panel C). The limit of quantitation (LOQ) for this assay as performed was 0.1 μg MAb/ml serum. P values for MAb 234 were <0.0001, <0.0001, 0.0016, and 0.325 for doses of 3 mg/kg, 1 mg/kg, 0.3 mg/kg, and 0.1 mg/kg, respectively. P values for MAb 338 were <0.0001, <0.0001, <0.0001, and 0.0064 for doses of 3.0 mg/kg, 1.0 mg/kg, 0.3 mg/kg, and 0.1 mg/kg, respectively. Nasal turbinate P values of statistical significance were 0.0006 () and <0.0001 (#). IgG, immunoglobulin G.