TABLE 3.
ORFs identified within the PsHV-1 and ILTV genomes
| PsHV1
|
ILTV
|
Length (aa)a
|
% Identity (to ILTV) | Putative functionb | |||
|---|---|---|---|---|---|---|---|
| ORF | Nucleotide position | ORF | Nucleotide position | PsHV1 | ILTV | ||
| UL54 | 4295-2376 | UL54 | 12082-10787 | 639 | 420 | 38 | Posttranslational regulator of gene expression |
| UL53 | 6461-5385 | UL53 | 13916-12855 | 358 | 337 | 31 | Glycoprotein K; exocytosis |
| UL52 | 10335-6454 | UL52 | 17176-13847 | 1,293 | 1,110 | 42 | DNA helicase-primase |
| UL51 | 10319-11101 | UL51 | 17189-17875 | 260 | 229 | 55 | Unknown |
| UL50 | 12476-11232 | UL50 | 19182-17935 | 414 | 416 | 46 | Deoxyuridine triphosphatase |
| UL49.5 | 12667-13014 | UL49.5 | 19336-19686 | 140 | 266 | 50 | Putative viral membrane protein |
| UL49 | 13184-14038 | UL49 | 19749-20546 | 283 | 117 | 50 | Viral tegument protein |
| Not present | UL48 | 20695-21882 | 396 | Viral tegument protein (α-TIF) | |||
| UL46 | 14500-16323 | UL46 | 21888-23558 | 606 | 539 | 44 | Tegument phosphoprotein; α-TIF modulation |
| UL45 | 17426-16521 | UL45 | 24559-23663 | 301 | 281 | 26 | Tegument/envelope protein |
| ORF A | 21070-22260 | ORF A | 25275-26405 | 396 | 376 | 27 | Hypothetical protein |
| ORF B | 22726-23829 | ORF B | 26448-27467 | 367 | 340 | 30 | Hypothetical protein |
| ORF C | 25174-24056 | ORF C | 28529-27528 | 372 | 334 | 33 | Hypothetical protein |
| ORF D | 25554-26654 | ORF D | 28639-29760 | 366 | 374 | 38 | Hypothetical protein |
| ORF E | 28424-27054 | ORF E | 31067-29838 | 456 | 410 | 28 | Hypothetical protein |
| UL22 | 31254-28834 | UL22 | 33539-31128 | 828 | 779 | 34 | Glycoprotein H; fusion complexes with gL |
| UL23 | 32569-31550 | UL23 | 34667-33576 | 339 | 363 | 40 | Thymidine kinase |
| UL24 | 32533-33489 | UL24 | 34556-35416 | 318 | 287 | 41 | Unknown |
| UL25 | 33628-35511 | UL25 | 35392-37107 | 627 | 572 | 47 | DNA packaging protein |
| UL26 | 35709-37382 | UL26 | 37288-39045 | 557 | 586 | 33 | Capsid protein p40 |
| UL26.5 | 37199-37891 | UL26.5 | 38428-39045 | 230 | 206 | 13 | Virion scaffold protein |
| UL27 | 40995-38260 | UL27 | 41747-39099 | 911 | 873 | 59 | Glycoprotein B |
| UL28 | 43743-41164 | UL28 | 44013-41722 | 859 | 537 | 47 | ICP18.5; cleavage/packaging |
| UL29 | 47426-43860 | UL29 | 47094-44098 | 1,188 | 999 | 59 | Major single-strand DNA binding protein |
| UL30 | 47858-51103 | UL30 | 47271-50291 | 1,081 | 1,007 | 54 | DNA polymerase |
| UL31 | 52171-51134 | UL31 | 51483-50467 | 345 | 339 | 68 | Nuclear phosphoprotein |
| UL32 | 54020-52164 | UL32 | 53233-51479 | 618 | 582 | 48 | Envelope glycoprotein |
| UL33 | 54019-54393 | UL33 | 53190-53579 | 138 | 119 | 58 | DNA packaging |
| UL34 | 54616-55440 | UL34 | 53611-54486 | 300 | 290 | 62 | Membrane-associated phosphoprotein |
| UL35 | 55567-55992 | UL35 | 54515-54886 | 141 | 124 | 50 | Capsid protein |
| UL36 | 65672-56085 | UL36 | 62584-54917 | 3,209 | 2,556 | 36 | Major tegument protein |
| UL37 | 69349-66437 | UL37 | 65881-63212 | 970 | 890 | 34 | Tegument protein |
| UL38 | 69618-71078 | UL38 | 65973-67280 | 486 | 412 | 41 | DNA binding; capsid protein |
| UL39 | 71339-73774 | UL39 | 67618-69972 | 818 | 785 | 50 | Large-subunit ribonucleotide reductase |
| UL40 | 73851-74792 | UL40 | 69827-70915 | 313 | 310 | 69 | Small-subunit ribonucleotide reductase |
| UL41 | 76206-74884 | UL41 | 72176-70983 | 440 | 398 | 73 | Virion host shutoff |
| UL42 | 76680-78182 | UL42 | 72398-73693 | 519 | 432 | 34 | Processivity factor for DNA polymerase |
| UL43 | 78100-79626 | UL43 | 73756-74970 | 508 | 300 | 11 | Unknown |
| UL44 | 80418-81806 | UL44 | 75683-76924 | 462 | 414 | 29 | Glycoprotein C |
| UL21 | 83761-82052 | UL21 | 78611-77016 | 569 | 532 | 28 | Nucleocapsid protein |
| UL20 | 84089-84835 | UL20 | 78782-79477 | 248 | 232 | 30 | Membrane protein |
| UL19 | 85082-89323 | UL19 | 79664-83872 | 1,413 | 1,403 | 65 | Major capsid protein |
| UL18 | 89684-90649 | UL18 | 84059-85015 | 321 | 319 | 64 | Capsid protein |
| UL15a | 92293-90773 | UL15a | 86212-85103 | 513 | 764 | 66 | Terminase; DNA packaging |
| UL17 | 92187-94634 | UL17 | 86355-88505 | 815 | 341 | 38 | Tegument protein |
| UL16 | 94538-95605 | Not present | 355 | Capsid assembly | |||
| UL15b | 96940-95588 | UL15b | 89761-88598 | 450 | 764 | 43 | Terminase; DNA packaging |
| UL14 | 96939-97529 | UL14 | 89595-90353 | 196 | 196 | 45 | Unknown |
| UL13 | 97403-98785 | UL13 | 90212-91606 | 486 | 465 | 45 | Serine/threonine protein kinase |
| UL12 | 99023-100585 | UL12 | 91750-93366 | 566 | 526 | 58 | Alkaline deoxynuclease |
| UL11 | 100585-100728 | UL11 | 93259-93502 | 48 | 80 | 42 | Myristoylated tegument protein |
| UL10 | 102288-101047 | UL10 | 94758-93580 | 413 | 393 | 46 | Glycoprotein M |
| UL9 | 102386-105028 | UL9 | 94653-97382 | 880 | 892 | 53 | Ori binding protein |
| UL8 | 105636-107582 | UL8 | 97378-99762 | 648 | 795 | 34 | Helicase-primase component |
| UL7 | 108856-107690 | UL7 | 100889-99816 | 388 | 358 | 41 | Unknown |
| UL6 | 110909-108561 | UL6 | 102807-100669 | 782 | 713 | 47 | Minor capsid protein |
| UL5 | 110993-113560 | UL5 | 102795-105314 | 855 | 840 | 58 | Helicase-primase component |
| UL4 | 113781-114539 | UL4 | 105403-105936 | 252 | 178 | 81 | Unknown |
| UL3 | 114921-115523 | UL3 | 106948-106349 | 200 | 196 | 66 | Unknown |
| UL2 | 115671-116759 | UL2 | 107950-107060 | 265 | 297 | 50 | Uracil DNA glycosylase |
| UL1 | 117253-116705 | UL1 | 107920-108279 | 182 | 131 | 32 | Glycoprotein L |
| Not present | UL0 | 111514-110171 | 447 | Unknown | |||
| UL[−1] | 118632-117331 | UL[−1] | 111670-112026 | 463 | 501 | 23 | Unknown |
| ICP4a | 127595-121494 | ICP4 | 118888-114500 | 2,033 | 1,463 | 35 | Gene regulation |
| US10 | 133103-133948 | US10 | 122103-122936 | 281 | 278 | 32 | Unknown |
| Not present | sORF4/3 | 124190-123309 | 293 | Unknown | |||
| US2 | 134374-134634 | US2 | 125011-124325 | 85 | 118 | 34 | Unknown |
| US3 | 136263-134785 | US3 | 125100-126527 | 498 | 471 | 48 | Protein kinase |
| sORF1 | 136535-138352 | UL47 | 126616-128484 | 605 | 623 | 45 | UL47 |
| US4 | 138546-139388 | US4 | 128651-129526 | 280 | 292 | 24 | Glycoprotein G |
| sORF2 | 139667-142642 | US5 | 129739-132693 | 991 | 985 | 18 | Glycoprotein J |
| US6 | 142740-143891 | US6 | 132441-133805 | 383 | 434 | 28 | Glycoprotein D |
| US7 | 144089-145315 | US7 | 133916-135001 | 492 | 362 | 34 | Glycoprotein I |
| US8 | 145663-147369 | US8 | 135198-136694 | 568 | 499 | 27 | Glycoprotein E |
| Not present | US9 | 136704-137483 | 259 | Unknown | |||
| sORF4/3 | 148377-149249 | sORF4/3 | 137535-138416 | 290 | 322 | 34 | Unknown |
| Not present | US10 | 138704-139402 | 232 | Unknown | |||
| ICP4b | 154577-160678 | ICP4 | 142837-147225 | 2,033 | 1,463 | 35 | Gene regulation |
a
aa, amino acids.
b
Function or property as demonstrated for the ILTV and/or HSV-1 homolog.