FIG. 2.

ADP-ribose binding. (A) Representation of the σA-weighted Fo-Fc Fourier map, contoured at 3σ, as identified in the B molecule of the SARS-CoV macro domain during the first round of refinement. The final model of the ADP-ribose molecule is displayed in purple sticks in the purple electron density. The protein is represented in ribbons and colored according to secondary structure (α-helices in red, β-strands in yellow, and connecting loops in green). (B) Isothermal titration calorimetry profile for the binding of ADP-ribose to SARS-CoV macro domain.