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Conformational changes upon ADP-ribose binding. Panels A and B display the surface of the SARS-CoV macro domain colored according to electrostatic potential (positive and negative charges are indicated in blue and red, respectively), in its unliganded (A) and ADP-ribose bound (B) forms. Upon ADP-ribose binding, conformational changes implicating mainly loops 2 and 3 result in a small closing of the pocket around its ligand.
